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KMID : 0525720160210040242
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Journal of Chitin and Chitosan
2016 Volume.21 No. 4 p.242 ~ p.246
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Preparation and Characterization of Chitosan Microparticles for Near Infrared Laser-Induced Drug Release
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Kim Min-Ah
Kim Mi-Ri
Lee Chang-Moon
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Abstract
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In this study, melanin and 5-fluorouracil (5-FU)-loaded chitosan microparticles were prepared and the drug release profiles from the microparticles were investigated under near infrared (NIR) 808 nm laser irradiation at 1.5 W/cm 2 for 5 min. The chitosan microparticles were uniform and spherical in shape. After irradiation of NIR 808 nm laser at 1.5 W/cm2 for 5 min, the temperature of the chitosan microparticle solution increased. As the concentration of the chitosan microparticles increases from 0.55 mg/mL to 2.75 mg/mL, the temperature of the microparticle solution increased with irradiation time. Under NIR 808 nm laser irradiation, 32.1±2.3% and 53.7±1.1% of 5-FU from the chitosan microparticles were released at pH 7.4 and 5.0, respectively. In other hand, without laser irradiation 23.9±1.6% and 26.9±2.0% of 5-FU were released from the chitosan microparticles at pH 7.4 and 5.0, respectively. All these results indicate that chitosan microparticles containing melanin could be used as a photo-induced drug release system.
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KEYWORD
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Chitosan microparticles, NIR laser, 5-fluorouracil, Drug release, Photothermal effect
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